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Celiac Disease and Immunobiology

March 22, 2016 | Author: | Posted in health and medicine, nutrition

Celiac Disease and Immunobiology

Celiac Disease

Celiac disease is a rare and unusual autoimmune disease of the small intestines that occurs mainly to persons who are genetically-predisposed ‘ to it (Lundin et al Storsrud et al . Celiac disease is also known as sprue , no tropical sprue , and celiac sprue ( Celiac Disease c . Generally , autoimmune diseases are mostly affected by a person ‘s genotype and the environment in which he or she is exposed to (Marrack et al . The disease is characterized by anomalous reactions to gliadin which is a form of gluten found [banner_entry_middle]

in cereals such as wheat barley and rye , although there are cases when a person afflicted with this disease also reacts to oats (Lundin et al Storsrud et al . Usually , the immune system of a person afflicted with Celiac disease reacts negatively whenever he or she consumes gluten which can ultimately result in injury of the delicate linings of the small intestine . Also Celiac disease makes the body unable to absorb many essential nutrients that the body needs to function properly such as vitamins , calcium , protein , carbohydrates and fats ( Celiac Disease b

How does the immune system responds to Celiac Disease

Celiac disease is similar to lactose intolerance as such that it makes a person intolerant to gluten (van de Wal et al . For example , Celiac disease causes a person ‘s immune system to be sensitive to gliadin . The infected person ‘s immune system negatively reacts to the enzyme tissue transglutaminase ( Coeliac Disease .This reaction causes the immune system to damage the villi (finger-like projections that absorbs nutrients ) in the small intestines . Damage to the villi causes the body to absorb fewer nutrients regardless of the amount of food taken in by the person . These symptoms in turn lead to malnutrition . Although Celiac disease is commonly classified as an autoimmune dis , these digestive symptoms also allows it to be classified as a malabsorption disease ( Celiac Disease a

What happens to people with celiac disease

The symptoms and complications brought about by Celiac disease vary from one situation to another . For infants , celiac disease may cause abdominal pains and various types of diarrhea (from common to bloody diarrhea . It may also cause stunted growth and weight loss . For young children , abdominal pain may be accompanied by nausea , appetite loss anemia , mouth sores and skin rash or dermatitis . For growing children celiac disease may cause the child to be irritable , agitated and emotionally distressed . Celiac disease at this stage may also lead to malnutrition and diarrhea which is usually accompanied by vomiting causing the child to have a large , hollow tummy and thin muscles in the thigh and buttock area . Celiac disease may afflict teenagers late into the puberty stage , causing major hair loss known as alopecia areata Celiac disease ‘s symptoms are worse for adults as it causes depression petulance , fatigue and the lingering feeling that one is in poor health although no apparent intestinal problems may be present . It may also lead to osteoporosis (loss of calcium in… [banner_entry_footer]

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